Neobrufen Retard 800mg
Neobrufen retard 800mg
40 tabletsActive ingredient: Ibrofen
effect
Ibuprofen is a drug that is mainly used to treat pain and inflammation, but can also reduce fever.A common use are mild to moderately severe pain such as headache, toothache or menstrual pain. Here often sufficient amounts of active compound of 200 to 400 milligrams of ibuprofen from. Furthermore, ibuprofen has been successfully used in migraine attacks.
The active compound is also administered in the treatment of injuries such as contusions blunt, sprains and strains, such as sports injuries.
Ibuprofen is also very common in the joints of alleviating severe to very severe pain. The active substance combats pain and inflammation alike. Arthritis or inflammatory rheumatic diseases that are treated with ibuprofen, are: gout, osteoarthritis, rheumatoid arthritis (also called rheumatoid arthritis) and inflammatory diseases such as ankylosing spondylitis vertebra. In inflammatory diseases of the joints relatively high doses of 800 milligrams of active ingredient are required.
In inflammatory rheumatic diseases of soft tissues (muscles and organs) and ibuprofen is also used.
In fibromyalgia, a painful soft tissue disease without inflammatory cause Ibuprofen is used to temporarily to fight the pain.
For older infants and children is ibuprofen in low doses as a juice available.
Application areas:
Pain (mild to moderate)
a headache
menstrual pain
toothache
fever
migraine
gout
arthrosis
inflammatory rheumatic diseases
inflammation
Pain (strong to very strong)
fibromyalgia
dosage
adults and adolescents aged 15 years and two to three times a day a prolonged release tablet to 800 milligrams. This corresponds to a daily dose from 1600 to 2400 milligrams.The maximum daily dose is 2400 milligrams of ibuprofen, ie three times a tablet.
The maximum single dose of 800 milligrams should not be exceeded.
The drug should be swallowed whole and with plenty of fluids with meals. Taking on an empty stomach is not recommended.
The application period determined by the physician.
side effects
Very common side effects:Gastrointestinal symptoms such as heartburn, abdominal pain, constipation, nausea and vomiting, diarrhea, slight bleeding in the gastrointestinal tract, bloating, gastrointestinal blood loss (slightly, cause only in exceptional cases anemia).
Common side effects:
Gastrointestinal ulcers (sometimes with bleeding and perforation), inflammatory oral ulcers, ulcerative colitis gain, Crohn's gain, headaches, dizziness, insomnia, agitation, irritability, fatigue.
Uncommon side effects:
Blurred vision, inflammation of the stomach, water retention in the tissues (especially in patients with hypertension or renal impairment), renal dysfunction (nephrotic syndrome, interstitial nephritis, and acute renal failure), rashes, itching, asthma attacks.
Very rare side effects:
Palpitations, fluid retention in the tissues (edema), heart failure, heart attack, blood formation disorders (anemia, white blood cell deficiency, thrombocytopenia, general blood cell deficiency, lack of granulocytes), ringing in the ears (tinnitus), inflammation of the esophagus, pancreatitis, intestinal strictures, Nierengewebsschädigungen (papillary necrosis), blood uric acid concentration increase, severe skin reactions (such as erythema multiforme, Stevens-Johnson syndrome, Lyell's syndrome), hair loss, deterioration of infections, meningitis (not bacteria, with neck stiffness, headache, nausea and vomiting, fever or clouding of consciousness), hypertension, severe general hypersensitivity reactions (facial edema, tongue swelling, internal laryngeal swelling with constriction of the airways, shortness of breath, rapid heartbeat, hypotension, shock), hepatic dysfunction, liver damage (especially in the long-term treatment), liver failure, hepatitis, psychosis.
interactions
The concomitant use of ibuprofen changed at following agents the effect:Digoxin (cardiac insufficiency), lithium (for depression), methotrexate (for cancer and rheumatism) or phenytoin (for epilepsy): There may be by increasing the blood concentration of these agents in poisoning.
Remedy for diabetes (oral agents, sulfonylureas): The blood glucose level lowering effect is increased, therefore a frequent medical examinations of blood glucose levels is necessary. Possibly the dose of antidiabetic agents should be adjusted by the physician.
Immunologicals as cyclosporin and tacrolimus: The nephrotoxic side effect is amplified.
Remedy for high blood pressure (antihypertensives), dehydrating agents (diuretics), sulfinpyrazone (to uric acid excretion, not common in Germany) are attenuated in the action.
potassium-sparing dehydrator: There may be excessive blood potassium concentration.
ACE inhibitors: effect attenuation, while increasing the risk of kidney damage.
the virus means Zidovudine: HIV-positive patients with hemophilia disease suffer more joint bleeding and bruising when taking concomitant zidovudine and ibuprofen.
Aspirin: The desired inhibition of platelet aggregation and thereby protecting against blood clots can be reduced.
But the effect of ibuprofen can be changed by the use of other agents:
Probenecid and sulfinpyrazone (both gout agents) reduce the ibuprofen excretion and therefore increase the risk of adverse effects.
By taking other NSAIDs (including so-called coxibs or COX-2 inhibitors), platelet aggregation inhibitors and selective serotonin reuptake inhibitors (for depression) or of glucocorticoids increases the risk of side effects, particularly the risk of gastrointestinal bleedings and -Geschwüren.
Simultaneous heavy drinking and oral anticoagulants such as warfarin increase the risk of bleeding.
For external use of ibuprofen is not expected to interact.
Note:
Concomitant administration of ibuprofen, and aspirin is not generally recommended. Regular long-term use of ibuprofen may possibly reduce the cardioprotective effects of low dose aspirin. Instead of ibuprofen can be resorted to if necessary diclofenac, which does not show this interaction.
In occasional ibuprofen use such an interaction is, however, not likely.
Contraindications
Inwardly and outwardly may ibuprofen not be used inHypersensitive (allergic) to the active substance
if after the use of similarly acting drugs (such as aspirin or other nonsteroidal anti-inflammatory drugs) asthma attacks, narrowing of the airways (bronchospasm), acute coryza (rhinitis) or red, itchy rashes occurred.
Inwardly may ibuprofen not be given at:
unexplained blood formation disorders
existing or past history of repeated gastric and duodenal ulcers or bleeding corresponding and breakthroughs, especially after treatment with NSAIDs
Bleeding in the brain or elsewhere in the body
severe liver or renal dysfunction
severe heart failure.
Only after a careful medical risk-benefit assessment by the physician and under his control must ibuprofen are used by:
concurrent treatment with other NSAIDs (including COX-2 inhibitors)
elderly
inflammatory bowel diseases such as Crohn's disease or ulcerative colitis in history
uncontrolled hypertension
and mild to moderate heart failure
Hypoperfusion of the heart muscle (ischemic heart disease)
Hypoperfusion of the brain
Occlusion of arteries in the arms or legs
acute metabolic disorders such as hepatic porphyria
Patients with certain immune diseases such as systemic lupus erythematosus or mixed connective tissue disease
Impairment of renal or hepatic function
State immediately after major surgery.
The long-term treatment of patients with risk factors for heart and vascular disease (eg, hypertension, dyslipidemia, diabetes or smoking) must be carefully considered by the physician, especially when high doses of ibuprofen (more than 2,400 milligrams / day) are required.
Patients who suffer from hay fever, nasal polyps and chronic pathological airway narrowing or have a general tendency to allergies, the active ingredient may internally and externally apply only under certain precautions and direct medical supervision.
What should I watch for pregnancy and breastfeeding?
Ibuprofen may harm the unborn baby, especially if the ingestion of the active ingredient takes place in the last third of pregnancy. For the first six months of pregnancy, the risk of birth defects is low, but pregnant women should also take prescription free Inuprofen only after careful benefit-risk assessment by the physician. given before birth, ibuprofen suppresses labor and thereby delayed the birth.Ibuprofen and its metabolites are excreted in human milk. During lactation is therefore particularly long-term therapy to refrain.
What has to be considered in children?
Ibuprofen is not suitable for children under six months. In older children, the age limit depends on the dosage of the drug. Here, the package leaflet must be consulted or to consult the doctor.
warnings
The ability to react may be adversely affected by taking the drug that driving a car or operate machinery are dangerous. This applies particularly in combination with alcohol.
When taking the drug over a prolonged period without medical supervision can cause serious side effects, particularly in the gastrointestinal tract, can occur.
With stiff neck, headache, nausea, vomiting, gastrointestinal bleeding, fever, blurred vision, or impaired consciousness immediately a doctor should be consulted.
When taking antidiabetics of blood glucose should be particularly carefully controlled and where appropriate, the antidiabetic dose adjusted medically.
With prolonged use of the drug and in the elderly, the renal and hepatic function should be checked regularly by a doctor.
With prolonged use of the drug, the blood count is regular medical control.
For facial and tongue swelling, shortness of breath, rapid heartbeat and blood pressure drop immediately the doctor must be informed.
The drug should not be used in patients who are taking aspirin to thin the blood.
With prolonged use of the drug headaches can occur which must not be treated with higher doses.
In hypertension and / or mild to moderate, discomfort-causing heart failure in the history of special medical control is necessary because the drug can cause fluid retention in the tissue.
The use of the drug, especially in high doses, is possibly associated with a slightly increased risk of heart attack and stroke.
The blood count, liver enzymes and renal function should be checked regularly on a long-term therapy.
Medicines can cause allergic reactions. The signs may be: rash, runny nose, itching, mucosal swelling, itching and redness of the eyes, narrowing of the airways (asthma). In rare cases there may be allergic shock with unconsciousness.
If you experience signs of an allergic reaction, so you immediately inform your doctor.
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