Andrucur 50 mg
50 tablets
Active ingredient: cyproterone
What is it and what is it used for?
Androcur is an antiandrogenic hormone preparation effective. It inhibits the influence of male sex hormones (androgens), which are formed to a lesser extent by the female organism.
When man let after during treatment with Androcur the sex drive and potency. The testicular function is inhibited. These changes after discontinuation of treatment back. Androcur shields androgen target organs, such as the prostate, from against the action of the originating from the gonads and / or the adrenal androgens.
When women are pathologically increased body hair, but also reduces androgen scalp hair loss and weakened increased sebaceous secretion. During treatment, ovarian function is inhibited.
It is used in men to drive loss sex drive in pathologically altered (Sexualdeviationen) and Antiandrogenbehandlung with inoperable prostate cancer.
It is used in women in case of severe androgenisation as pathologically increased facial and body hair (severe hirsutism) and androgenetic strong scalp hair loss to baldness (severe androgenetic alopecia), often associated with severe forms of acne and / or oily skin and oily hair with dandruff (seborrhea).
The preparation is women only prescribed if a treatment with a lower dose preparation no satisfactory success has been achieved.
Androcur may only be used when prescribed by a physician or health care professional and under the constant supervision of a doctor or a health care professional.
What you need to consider before using it?
In women a thorough general and gynecological examination must be performed prior to initiating therapy. In patients in puberty, pregnancy should be ruled out.
Androcur is together with a special oral Em¬pfängnisverhütungsmittel apply (e.g., Diane-35) to achieve the necessary contraception and to prevent irregular bleeding.
If a slight bleeding "outside the range" comes under the combination treatment within the three week cycle, the application is not to interrupt, at any severe bleeding, however, the doctor or the doctor's visit.
During treatment, the liver function, adrenal cortex and the red blood cell count should be monitored.
In addition, to comply with all applicable information for this preparation in conjunction with the necessary additional gift of the prescribed contraceptive.
In women
- Pregnancy.
- Lactation.
- Liver disease.
- Dubin-Johnson syndrome, Rotor syndrome (certain Aussscheidungsstörungen the liver).
- Jaundice (jaundice) or persistent pruritus (persistent itching) during a previous pregnancy.
- Pregnancy Herpes in prehistory.
- Preceding or existing liver tumors.
- Wasting diseases.
- Severe chronic depression.
- Preceding or existing thromboembolic events (blood clots in the blood vessels).
- Severe diabetes with vascular changes.
- Sickle cell disease (a congenital disorder of red blood cells).
- Hypersensitivity to any component of Androcur.
In cyclic combination treatment of severe Androgenisierungsanzeichen note also the information on contraindications in the prescribing information of Diane-35 or from another contraceptive, which is used in combination with Androcur.
When man
Drive loss at Sexualdeviationen
- Liver disease.
- Dubin-Johnson syndrome, Rotor syndrome (certain Aussscheidungsstörungen the liver).
- Preceding or existing liver tumors.
- Wasting diseases.
- Severe chronic depression.
- Preceding or existing thromboembolic events (blood clots in the blood vessels).
- Severe diabetes with vascular changes.
- Sickle cell anemia.
- Hypersensitivity to any component of Androcur.
Antiandrogen treatment of inoperable prostate cancer
- Liver disease.
- Dubin-Johnson syndrome, Rotor syndrome (specific excretion disorders of the liver).
- Preceding or existing liver tumors (only if not caused by prostate cancer metastasis).
- Wasting diseases (with the exception of inoperable prostate cancer).
- Severe chronic depression.
- Thromboembolism (formation of clots in the vessels).
- Hypersensitivity to any component of Androcur.
Androcur tablets should not be used in children or adolescents.
In individual cases were reported during treatment with the active ingredient of Androcur like other sex steroids, benign and malignant liver changes. Liver tumors can occasionally lead to fatal bleeding into the abdominal cavity. Therefore necessarily inform the physician / health care professional if unusual upper abdominal discomfort, does not go away by itself soon.
View may change due to Androcur your doctor or health care professional if you suffer from diabetes, as this disease requires careful monitoring and the need for drugs against diabetes.
Occasionally, Androcur lead to a feeling of shortness of breath.
The occurrence of thromboembolic events (blood clots in the vessels) in patients receiving Androcur are reports, but a causal relationship has not been created. Patients with previous arterial or venous thrombotic / thromboembolic events (for example, deep vein thrombosis, pulmonary embolism, heart attack), cerebrovascular events (for example, stroke) in the history or with advanced malignancies are at increased risk of further thromboembolic events.
If concomitant use of alcohol is possible because of its anxiolytic influence a reduction in operating depressant effects of Androcur.
Patients with inoperable prostate cancer, thromboembolic events in prehistory or patients suffering from sickle cell anemia or severe diabetes with vascular changes, must inform their physician or their physician. These are prior to prescribing Androcur in each individual case, perform a careful risk-benefit assessment.
Under higher doses of cyproterone acetate is a tendency to slightly elevated prolactin levels (directed to milk production hormone) was occasionally observed.
In male patients Androcur may lead to enlargement of the breast. The prolonged use can lead to osteoporosis (brittle bones) in men.
Taking other medicines
The need for antidiabetic agents or insulin may change due to worsening of glucose tolerance.
Inform, also have your doctor or pharmacist or your doctor or pharmacist if you are suffering from other diseases allergies or other medicines (including those purchased) are taking or applying externally.
These include in particular drug with ketoconazole, itraconazole, clotrimazole (against fungal infections), ritonavir (against AIDS), rifampicin (used to treat seizures), phenytoin, products containing St. John's wort (plant remedy for depression), and products that belong to the group of statins ( drugs, reduce that elevated blood lipids, including cholesterol and triglycerides).
Medicines for blood fat reduction
The risk of serious statin-related adverse effects in muscle tissue (called myopathy or rhabdomyolysis) may be increased when they are administered with high therapeutic doses of Androcur, because the active ingredients of this product are subject to the same pathway.
Effect on the ability to drive and use machines
This medicine may responsiveness, the ability to use tools or machines and driveability.
Androcur can adverse effects on the unborn child and - also on the infant - breastfeeding. Therefore, it should only be used under any circumstances during pregnancy or during lactation.
How is it used?
The tablets should be taken after meals with liquid.
Usual dosage in men
The respective dose determined by the physician or health care professional.
Drive loss sex drive in pathologically altered (Sexualdeviationen)
For initial treatment, the daily dose is generally 2 times 1 tablet. It may be necessary, even daily to increase the dose to 2 times daily 2 or 3 times 2 tablets temporarily. If a satisfactory outcome has been reached, is trying to maintain the therapeutic effect with the lowest possible dose. Often enough 2 times daily ½ tablet. When set to a maintenance dose at weaning and never abruptly, but tapered off reduced. Here, at intervals of a few weeks, the daily dose to 1
What are possible side effects?
The following side effects may occur when taking Androcur:
Both genders
Common: weight gain or weight loss, loss of volition, some restlessness, fatigue, jaundice, hepatitis, hepatic insufficiency.
Uncommon: depressed mood, skin rashes, shortness of breath.
Rare: hypersensitivity reactions (allergy-like reactions), thromboembolic reactions, thromboembolic events (blood clots in the vessels), liver tumors.
Men
Very common: decreased sex drive, erectile dysfunction (impotence), reversible inhibition of sperm production (spermatogenesis).
Common: Gynecomastia (swelling of the mammary glands) sometimes along with a sensitivity to touch the nipples, hot flushes and sweating.
Very rare: osteoporosis (brittle bones).
women
Very common: suppressing ovulation.
Common: feeling of tension in the chest.
Uncommon: decreased sex drive, galactorrhea (milk flow).
Rare: Increased sexual drive.
In connection with the long-term use (several years) of Androcur at doses of 25 mg or higher benign brain tumors (meningiomas) were reported.
With regard to the necessary additional administration of a contraceptive such as Diane-35 is made to the specific notes relating to adverse effects in the SPC of this preparation.
If you notice any side effects that are not described here, you should tell your doctor or pharmacist or your doctor or pharmacist.
