Utrogestan / Seidigestan 100
30 softgels
Active substance: progesterone
What is it and what is it used for?
Utrogestan contains the active ingredient progesterone, a female sex hormone the group of progestogens. Progesterone is secreted by the ovaries. It plays an important role in regulating the female menstrual cycle and normal pregnancies. The progesterone contained in the Utrogestan capsules corresponds in structure to the physiological (natural) form of the hormone produced in the course of the menstrual cycle. The special, called micronized pharmaceutical form adds a prolonged operative time.
Utrogestan is applied on prescription as an adjunct to treatment with estrogen, a different type of female sex hormone, and in certain cases a progesterone deficiency.
Depending on the treatment Utrogestan capsules by mouth (orally) or the vagina (vaginal) administered.
Oral administration
In women with intact uterus as part of a hormonal treatment of (natural or occurring as a result of removal of ovaries) menopausal symptoms as a supplement to estrogen treatment. The combination of the two hormones reduced the increased risk of cervical cancer, is adjusted for the sole administration of an estrogen.
Menopausal symptoms are primarily manifested in hot flashes, sweating, palpitations, sleep disorders and / or mental health problems, such as irritability and depressed mood.
However Depressive states can only be influenced by such treatment, if they are directly related with the hot flashes.
Premenopausal (period before menopause, physical and emotional complaints: see above).
Premenstrual Syndrome (physical and emotional symptoms that occur a few days before the start of menses).
Menstrual irregularity, provided that they are shown to be due to hormonal disturbances and no pathological changes in the ovaries or uterus.
Vaginal administration
Menstrual disorders and infertility due to a proven progesterone deficiency in the context of medically assisted reproduction program after stimulation of oocyte maturation by other hormones.
What you need to consider before using it?
Before beginning treatment, you will undergo the doctor uses a thorough gynecological examination, and it is essential that you follow his or your instructions.
Utrogestan may not be used in:
Hypersensitivity to progesterone or peanut protein (The capsule contains peanut oil as ingredient) or any of the ingredients of the preparation;
in liver tumors or other serious current or previous liver disease;
with suspected or proven breast or uterine cancer;
Uterine or vaginal bleeding of unknown origin;
arteriell- or venenthromboembolische disorders, cerebral hemorrhage.
Furthermore, you may not use Utrogestan, has exacerbated when at you during a previous pregnancy or hormone treatment, a sex hormone-dependent disorder or adjusted for the first time, so as jaundice, severe itching, a certain type rash (called pregnancy herpes) or a certain type metabolic disorder of the liver (porphyria).
If Utrogestan has been prescribed as an adjunct to an estrogen preparation (for example for hormone replacement treatment) are general precautions valid. Please also refer to the patient information of estrogen.
Bleeding may occur early in treatment. These usually disappear after a few cycles of treatment. However, if they persist and / or become stronger and / or irregular, you must inform your doctor so that he can rule out any organic disorders.
Unlike vaginal administration Utrogestan should not be given orally during pregnancy. Before the beginning of oral therapy, pregnancy should be ruled out.
Mandatory grounds for immediate discontinuation of treatment
The first signs of thromboembolic or thrombophlebitischen disorders (eg pain or swelling of the limbs, chest pain, acute visual disturbances, new onset of strong, unusual or migraine headaches), sudden signs of cerebrovaskülaren event or sudden large increase in blood pressure, signs of unusual pain in the upper abdomen, the not quickly pass by itself, of itching, appearance of jaundice, or first recurrence of depression.
Your doctor will tell you that the risk of a thromboembolic disorder may be increased by various factors. These factors include high blood pressure (hypertension), varicose veins, severe diabetes, previous thrombosis treatments and obesity and smoking.
It is therefore important that you tell your doctor if you suffer from asthma, migraine, convulsions (epilepsy) or kidney, liver or heart disease suffer, as these may be aggravated by fluid retention.
Utrogestan may affect the metabolism of sugar (glucose). If you have diabetes and are taking antidiabetic drugs, you must consult your doctor thereof as may require an adjustment of the dosage of the antidiabetic is required. Only the doctor can decide on such an adjustment.
Furthermore, the treatment (for example, after an accident) as well as 6 weeks is to be interrupted before elective surgery and in case of prolonged bed rest.
Some people Utrogestan can cause dizziness and a transient sleepiness.
How is it used?
Utrogestan may be administered (by mouth) or vaginally (via the vagina) orally. Administration, dosage and duration of treatment will be determined by your doctor.
Oral administration
In addition to hormone replacement treatment during and after menopause, the dosage is generally 2 capsules Utrogestan 100 mg to 12 to 14 consecutive days during each monthly estrogen treatment cycle. Usually occurs 3 to 5 days after taking the last Utrogestan capsule vaginal bleeding on (which is comparable to a normal menstrual period).
For complaints premenopausal for premenstrual symptoms and menstrual irregularities capsules Utrogestan be prescribed to 100 mg daily are generally 2 to 3, each for 10 days, that is, are from 17 to 26 days of the menstrual cycle, take.
The dosage of 2 capsules Utrogestan to 100 mg may be replaced by 1 capsule Utrogestan to 200 mg.
Vaginal administration
In menstrual disorders, the dosage is generally 2 to 3 capsules of 100 mg daily, each for 10 days, namely from 17 to 26 days of the menstrual cycle, take.
As part of a program to medically assisted procreation, the dosage is usually 4 capsules of 100 mg a day from the date on which the doctor has injected another hormone to trigger ovulation. After that, proceed with vaginal administration of Utrogestan most up to the 12th week of pregnancy.
Thus, the capsules can reveal their full effectiveness, they must be inserted deep into the vagina.
The dose of 4 capsules Utrogestan to 100 mg can be replaced by 2 capsules Utrogestan to 200 mg.
Do not change from the prescribed dose.
If you think the medicine is too weak or too strong, talk to your doctor or pharmacist.
What are possible side effects?
Oral administration
The following side effects may occur when taking Utrogestan:
Common: irregular menstrual periods or "spotting" (spotting between regular menstrual periods, generally during the first two months of therapy), headaches.
Uncommon: distension in the breasts, drowsiness, dizziness, depression; Itching, rashes (hives), jaundice, acne, skin spots, gastrointestinal symptoms such as nausea, vomiting.
Rare: weight gain, change in glucose tolerance.
Report of 2 occasional hypersensitivity reactions (allergy with erythema, sweating, palpitations, in certain cases with dizziness to fainting).
Vaginal administration
Rare: Local intolerance (burning, itching, or greasy discharge) or general side effects (drowsiness, dizziness).
Consult the undesirable effects your doctor occurrence.
The appearance of a number of adverse side effects due to immediate discontinuation of treatment (see "Take special care when applying Utrogestan?").
How should it be stored?
The drug should be kept out at room temperature (15 to 25 ° C) and for children. It may only be used up to the designated date on the package.
In case of biopsy-prescription you must inform the staff that you use this progestin treatment.
Further information can be obtained from your doctor or pharmacist who has the full prescribing information.
