Dormidina 25 mg

14 sleeping pills
Active ingredient: doxylamine

For falling and staying asleep
If sleep impossible and the next morning is a pain, Dormidina can shorten sleep time, without addictive.
Sleep disorders represent a major health problem. Whether one is asleep or awake is in the brain regulates on certain messenger substances. The activation system stands in rhythmic alternation with the inflammatory system, the sleep state. The activating messenger is histamine, which maintains the awake state when in contact with the so-called H-1 receptors.
To sleep, the messenger must therefore be switched off. Given the soporific Dormidina with the active ingredient doxylamine succinate can help.

What's Dormidina and what it is used

Doxylamine is an antiallergic drug from the group of antihistamines 1st generation with soothing and sleep-inducing properties. It is used as a mono-preparation primarily for the treatment of insomnia and taken to a half hour before bedtime. Doxylamine is also contained in cold remedies, and there are other areas of application. In contrast to the newer antihistamines of the second generation doxylamine is not selective for the histamine H1 receptor, but additionally anticholinergic and central effect. The active substance is not undisputed because of its adverse effects. The most common possible side effects include fatigue, reduction in responsiveness, paradoxical reactions, headaches and anticholinergic side effects such as dry mouth, accommodation disturbances, constipation and urinary retention.
effects
Doxylamine has antihistaminic, antiallergic, soothing, steaming, sleep-inducing and anti-emetic properties. The effects are due to the antagonism at histamine and muscarinic receptors. Doxylamine has a half-life of about 10 hours. Unlike modern antihistamines doxylamine 2nd generation is not selective for the H1 receptor and centrally effective.

indications

Doxylamine is in Switzerland for short-term treatment of anxiety associated with difficulty falling asleep, for the treatment of allergic rhinitis (hay fever, for example) and for the treatment of influenza and cold symptoms (combined preparations) approved.
Elsewhere it is also for other applications such as morning sickness combined with pyridoxine (Diclectin® in Canada, Diclegis® in the US, retarded), urticaria or staying asleep used, is permitted, but not registered in Switzerland.

dosage

According to the prescribing information. The drops are taken up to three times per day with meals or sleep for half an hour before bedtime.

abuse

Doxylamine can be abused because of its absorbing and anticholinergic properties. In practice, it is observed that it is also used for long-term treatment of sleep disorders for which there is not provided. In the literature, suicide attempts have been reported to a toxic overdose. The actor Heath Ledger (The Dark Knight, Brokeback Mountain) died of a drug cocktail, which contained, among other things doxylamine.

Contraindications

    hypersensitivity
    Acute asthma attack
    narrow-angle glaucoma
    pheochromocytoma
    Voiding dysfunction with urinary retention
    epilepsy
    Concomitant treatment with MAO inhibitors
    Acute alcohol or drug intoxication
    Children under 12 years

The full precautions can be found in the drug prescribing information.

interactions

Coadministration central depressants, alcohol and anticholinergics can lead to increased effect and is not recommended. Further interactions were described with phenytoin, antipsychotics, ototoxic substances and adrenaline.

unwanted effects

The most common possible side effects include fatigue, reduction in responsiveness, paradoxical reactions such as agitation and hallucinations in children and the elderly, headache and anticholinergic side effects such as dry mouth, accommodation disturbances, constipation and urinary retention. Rarely, cardiovascular reactions such as a deep or high blood pressure or heart palpitations occur.

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