Celebrex 200 mg celecoxib
30 capsules
Active ingredient: celecoxib
General
The active ingredient Celecoxib is used for irritation from degenerative joint disease (so-called active arthritis) as well as frequent inflammation of the joints (known as rheumatoid arthritis from the group of inflammatory rheumatic diseases), to relieve pain and reduce inflammation stimuli. Celecoxib may also be used for relief of discomfort from the inflammatory spinal disorder ankylosing spondylitis.
What is the purpose of this drug?
reduce symptoms in degenerative joint disease
reduce symptoms in frequent joint inflammation (arthritis)
reduce joint irritation
reduce symptoms in inflammatory spinal disorder (ankylosing spondylitis)
Contraindications
Below you will find information on contraindications in the use of celecoxib in general, during pregnancy and lactation and in children. Please note that the contraindications depending on the dosage form of a drug (eg, tablet, spray, ointment) may be different.
When should celecoxib not be used?
Celecoxib should not be used in:
Hypersensitive to the active ingredient and sulfonamides (active against bacteria)
Patients after taking aspirin (non-opioid painkillers) or other NSAIDs showed allergic reactions such as asthma, acute rhinitis, nasal polyps, mucosal swelling and hives
Heart disease due to narrowing of the coronary arteries, moderate to severe heart failure (NYHA stages II - IV.)
calcification of brain blood vessels
Stomach ulcers or ulcers in stomach bleeding or intestinal bleeding and in inflammatory bowel disease
severe hepatic impairment
severe kidney damage.
In addition, women should avoid in childbearing age without safe contraception protection on the use of celecoxib.
Only after strict medical benefit-risk assessment should be administered celecoxib with
significant risk factors for the occurrence of cardiovascular disease
significant risk factors for the development of disorders in stomach and intestines
Combination with anticoagulant drugs (anticoagulants).
Elderly patients should receive careful monitoring physician during treatment with celecoxib.
Some people have a deficiency of the enzyme CYP2C9 which is necessary for the degradation of celecoxib. The Blutonzentrationen of celecoxib are probably markedly increased in such patients. If the enzyme deficiency known, individuals should be treated with medical care.
What should I watch for pregnancy and breastfeeding?
There are no clinical data on application risks of celecoxib in pregnant women. However, malformations were detected in studies on rats. The potential risk for humans during pregnancy is unknown but can not be excluded. Moreover, celecoxib may cause an inhibition of uterine contractions. Celecoxib is therefore in pregnancy not apply. The same applies for the lactation. Here transitioning of the drug was observed in the breast milk in animal experiments.
What has to be considered in children?
Celecoxib is not suitable for use in children.
Possible side effects of celecoxib have?
Below the most important information on possible common side effects of celecoxib. These side effects do not occur, but can. Because each person reacts differently to medications. Please also note that the side effects in nature and frequency depending on the dosage form of a drug (eg, tablet, spray, ointment) may be different.
Common side effects:
Sinusitis, respiratory infections, insomnia, dizziness, pharyngitis, rhinitis, abdominal pain, diarrhea, dyspepsia, flatulence, rash, Gewebswassereinlagerung (edema).
Uncommon side effects:
Urinary tract infections, anemia, blood potassium increase, anxiety, depression, fatigue, blurred vision, muscle tension increase, numbness, ringing in the ears, heart attack, heart failure, heart palpitations, high blood pressure, worsening of hypertension disease, cough, shortness of breath, constipation, belching, gastritis, stomatitis, vomiting, liver dysfunction, hives, leg cramps, worsening of inflammatory bowel disease, liver enzyme appreciation, kidney values increase, blood urea concentration increase.
Rare side effects:
Individual blood cells decreases, platelet reduction, movement disorder, dysgeusia, stroke Duch artery occlusion, esophageal ulcers, gastric ulcers, small intestine ulcers, colon ulcers, dysphagia, intestinal perforation, oesophagitis, melaena, Hautpigmentierungszunahme, alopecia, photosensitivity.
Very rare side effects:
Reduction of all blood cells, confusion, delusions, epilepsy deterioration, meningitis, loss of taste, smell loss, Hörleistungsminderung, vascular inflammation, bronchoconstriction, menstrual disorders, stomach bleeding, intestinal bleeding, acute pancreatitis, colitis, hepatitis, jaundice, liver failure, vascular swelling, severe skin reactions such as peeling dermatitis and Stevens-Johnson syndrome, muscle inflammation, renal failure, nephritis.
What interactions shows celecoxib?
Please note that the interactions depending on the dosage form of a drug (eg, tablet, spray, ointment) may be different.
Celecoxib should not be administered concomitantly with inhibitors of blood clotting (anticoagulants) such as warfarin. This can lead to bleeding with partially fatal.
Cyclosporin and tacrolimus, immunologicals, which are used in autoimmune diseases, are amplified in its nephrotoxic effect.
With simultaneous use of low-dose acetylsalicylic acid (a non-opioid analgesics) creates an increased risk of complications from ulcers.
Celecoxib should not be administered with ACE inhibitors and Angiosin-II inhibitors (both groups of anti-hypertensives). The combination with these cardiovascular-active substances can lead to acute renal failure.
Basically antihypertensive agents (antihypertensives) and dehydrating agents (diuretics) with celecoxib can be reduced in their effect.
During celecoxib treatment, the blood levels of dextromethorphan soar, an antitussive drug. The effect of the agent may be enhanced cough. The same applies to drugs for depression (antidepressants), neuroleptics and other psychotropic drugs such as citalopram, imipramine and diazepam and agents against cardiac arrhythmias.
Fluconazole, an anti-fungus diseases, causes an increase of celecoxib concentration in the blood and can thus also result in an increased effect.
Rifampicin (tuberculosis agent), however, may antagonize the effects of celecoxib. The same applies to carbamazepine (an antiepileptic drug), and barbiturates (sedatives).
The combination of methotrexate, a Immunologikum, celecoxib should be monitored medically appropriate. Although lithium, a drug for depression, is administered the same time, careful medical supervision is necessary.
Warnings and Precautions
Due to the risk of side effects on the heart and vessels, the drug should be administered at the lowest effective dose for the shortest possible period.
The drug does not affect blood-thinning enough to forego a necessary anticoagulant treatment.
With deterioration of renal function, the treatment should be withdrawn.
At the first appearance of skin rash, mucosal damage or other signs of hypersensitivity reactions, treatment with the drug should be discontinued.
The drug may mask fever and other signs of inflammation.
During treatment with the drug must be taken for safe contraception.
People with a deficiency in the enzyme CYP2C9 may need a lower dosage of the drug.
The drug may reduce the ability to react, so that the use on the road and use machines are dangerous.
Simultaneous alcohol consumption also reduces the ability to react.
Sometimes medicinal substances trigger allergic reactions. If you experience signs of an allergic reaction, so you immediately inform your doctor or pharmacist.
