Nolotil capsules
20 piece
Active ingredient: Metamizole
Metamizole, also known as Novaminsulfon, is one of the most important active ingredients for severe pain, high fever and convulsions. The active ingredient is in medicines as a salt (metamizole sodium). This is very well soluble in water and can therefore be administered as an emergency drug even in acute disease complaints via an infusion. But there are also metamizole drops and tablets. Here you can read all important information about Metamizole.
This is how Metamizole works
Pain is part of the vital protection and warning system of the human body. In the case of injuries, the concentration of certain messenger substances (prostaglandins) increases in the tissue. When these bind to their docking sites (receptors), the nervous system forwards signals to the brain. These are processed there and as a result one feels pain.
Metamizole is converted into its active form in the body and as such inhibits the production of specific prostaglandins mainly in the brain and spinal cord (central nervous system). This prevents the formation of pain and, as a result, pain perception.
The antipyretic effect of metamizole is due to an influence on the temperature regulation center in the brain.
The release of convulsions (spasmolysis) is probably due to an inhibition of the transmission of stimuli to the so-called smooth muscles (gastrointestinal tract, urinary tract, uterus).
Absorption, breakdown and excretion of metamizole
When taken by mouth (orally), the active substance metamizole is still converted in the intestine. The resulting active compound is then completely absorbed into the blood and develops its maximum effect after about one and a half hours. In the liver, the substance is metabolized and finally excreted via the kidney.
If metamizole sodium is administered via an infusion, the effect occurs immediately. The further breakdown in the liver and excretion via the kidney are as if taken orally.
When will Metamizole be used?
The indications (indications) of Metamizol include:
Severe pain, including tumor pain
High fever
This is how Metamizole is applied
The usual dose of metamizole (oral or infusion) is approximately 0.5 to one gram a day in adults. If necessary, the dose can be increased up to four grams per day. In children and patients with hepatic or renal impairment, the dose must be reduced.
What are the side effects of Metamizole?
The active ingredient is usually well tolerated. Possible metamizol side effects include allergic skin reactions and hypotension. These side effects are uncommon, ie 0.1 to 1 percent of those treated. Rarely, there is a severe deficiency of a specific subgroup of white blood cells, the granulocytes. Possible signs of this so-called agranulocytosis are sudden fever, inflammatory mucosal changes and sore throat. If any of these symptoms occur, Metamizole sodium should be discontinued immediately and the blood count monitored by the attending physician.
What should be considered when taking Metamizole?
Contraindications
In asthma patients, taking Metamizole may trigger asthma attacks. You must therefore not receive any medications containing this substance. The same applies to patients with a specific enzyme deficiency (glucose-6-phosphate dehydrogenase deficiency) or disorders of the bone marrow function.
interactions
Metamizole can reduce the concentration of cyclosporin in the blood and thus its effectiveness. Therefore, caution should be exercised when taking both drugs at the same time. Ciclosporin is used in autoimmune diseases and organ transplants to suppress the immune system.
pregnancy and breast feeding period
The use of metamizole during pregnancy and breastfeeding should be avoided, since so far only very few experiences have been collected. Instead, better alternatives should be used (paracetamol for pain and fever, ibuprofen for inflammatory diseases).
Age restrictions
Infants under the age of 3 months or less than five kilograms should not receive the active substance as there is insufficient data for safe treatment.
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